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Version: 17.06d (Release date: 2017-06-26)
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Fluticasone Propionate (Code C29061)

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Terms & Properties

Preferred Name: Fluticasone Propionate

Definition: The propionate salt form of fluticasone, a synthetic trifluorinated glucocorticoid receptor agonist with antiallergic, antiinflammatory and antipruritic effects. Binding and activation of the glucocorticoid receptor results in the activation of lipocortin that in turn inhibits cytosolic phospholipase A2, which triggers cascade of reactions involved in synthesis of inflammatory mediators, such as prostaglandins and leukotrienes. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leads to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, which is essential for prostaglandin production.

Display Name: Fluticasone Propionate

Label: Fluticasone Propionate

NCI Thesaurus Code: C29061 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0117996  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic Acid, S-(Fluoromethyl) Ester
Flonase
Flovent
Fluticasone Propionate
FLUTICASONE PROPIONATE

External Source Codes: 
CAS Registry Number 80474-14-2 (see NLM ChemIDplus info)
FDA UNII Code O2GMZ0LF5W
ChEBI ID CHEBI:31441 (see ChEBI info)
PDQ Closed Trial Search ID 682628
PDQ Open Trial Search ID 682628 (check for NCI PDQ open clinical trial info)
UMLS CUI C0117996

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C25H31F3O5S
code C29061
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Fluticasone_Propionate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C29061

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