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Version: 17.06d (Release date: 2017-06-26)
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Fluocinonide (Code C29056)

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Terms & Properties

Preferred Name: Fluocinonide

Definition: A synthetic glucocorticoid and derivative of fluocinolone acetonide with anti-inflammatory and antipruritic activities. Fluocinonide binds the glucocorticoid receptor, followed by translocation of the ligand-receptor complex to the nucleus and transcription activation of genes containing glucocorticoid-responsive elements. Lipocortin-1 is one factor induced by fluocinonide that interacts and inhibits cytosolic phospholipase 2 alpha, thereby preventing phospholipase translocation to the perinuclear membrane and subsequent release and conversion of arachidonic acid to inflammatory prostaglandins. In addition, MAPK phosphatase 1 is induced, thereby preventing the triggering of the MAPK cascade resulting in pro-inflammatory effects via Jun N-terminal kinase and c-Jun. Finally, fluocinonide binds to and inhibits nuclear factor kappa-B directly, resulting in inhibition of cyclooxygenase 2 transcription and subsequent prostaglandin synthesis.

Label: Fluocinonide

NCI Thesaurus Code: C29056 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0016299  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(6alpha,11beta,16alpha)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
FLUOCINONIDE
Fluocinonide
Lidex
Vanos

External Source Codes: 
CAS Registry Number 356-12-7 (see NLM ChemIDplus info)
FDA UNII Code 2W4A77YPAN
NSC Code 101791 (see NCI DTP info)
UMLS CUI C0016299

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For plaque-type psoriasis
Chemical_Formula C26H32F2O7
code C29056
Contributing_Source FDA
Legacy_Concept_Name Fluocinonide
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C29056

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