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Version: 16.10e (Release date: 2016-10-31)
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Fenofibrate (Code C29047)

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Terms & Properties

Preferred Name: Fenofibrate

Definition: A synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity. Fenofibrate is hydrolyzed in vivo to its active metabolite fenofibric acid that binds to and activates peroxisome proliferator activated receptor alpha (PPARalpha), resulting in the activation of lipoprotein lipase and reduction of the production of apoprotein C-III, an inhibitor of lipoprotein lipase activity. Increased lipolysis and a fall in plasma triglycerides, in turn, leads to the modification of the small, dense low density lipoporotein (LDL) particles into larger particles that are catabolized more rapidly due to a greater affinity for cholesterol receptors. In addition, activation of PPARalpha also increases the synthesis of apoproteins A-I, A-II, and high density lipoprotein (HDL)-cholesterol. Overall, fenofibrate reduces total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) while increasing HDL cholesterol.

NCI-GLOSS Definition: A drug used to treat high levels of cholesterol and triglycerides in the blood. Fenofibrate is being studied in the treatment of advanced cancers in young patients and in the treatment of other conditions. It is a type of antilipidemic agent.

Display Name: Fenofibrate

Label: Fenofibrate

NCI Thesaurus Code: C29047 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0033228  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Fenofibrate
FENOFIBRATE
fenofibrate
Lofibra
TriCor
Tricor

External Source Codes: 
CAS Registry Number 49562-28-9 (see NLM ChemIDplus info)
FDA UNII Code U202363UOS
ChEBI ID CHEBI:5001 (see ChEBI info)
PDQ Closed Trial Search ID 459750
PDQ Open Trial Search ID 459750 (check for NCI PDQ open clinical trial info)
UMLS CUI C0033228

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C20H21ClO4
code C29047
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Fenofibrate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C29047

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