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Version: 17.12d (Release date: 2017-12-26)
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Esomeprazole Magnesium (Code C29032)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Esomeprazole Magnesium

Definition: The magnesium salt of esomeprazole, the S-isomer of omeprazole, with gastric proton pump inhibitor activity. In the acidic compartment of parietal cells, esomeprazole is protonated and converted into the active achiral sulphenamide; the active sulphenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting its activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. H+/K+ ATPase is an integral membrane protein of the gastric parietal cell.

NCI-GLOSS Definition: A drug that blocks acid from being made in the stomach. It is used to treat acid reflux disease and to prevent certain types of gastrointestinal ulcers. Esomeprazole magnesium is being studied in the prevention of esophageal cancer and in the treatment of other conditions, including side effects of chemotherapy. It is a type of anti-ulcer agent.

Display Name: Esomeprazole Magnesium

Label: Esomeprazole Magnesium

NCI Thesaurus Code: C29032 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0937622  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Esomeprazole Magnesium
esomeprazole magnesium

External Source Codes: 
CAS Registry Number 217087-09-7 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 367246
PDQ Open Trial Search ID 367246 (check for NCI PDQ open clinical trial info)
UMLS CUI C0937622

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula 2C17H18N3O3S.Mg.3H2O
code C29032
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Esomeprazole_Magnesium
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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