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Version: 17.06d (Release date: 2017-06-26)
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Efavirenz (Code C29027)

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Terms & Properties

Preferred Name: Efavirenz

Definition: A synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. Efavirenz binds directly to the human immunodeficiency virus type 1 (HIV-1) RT, an RNA-dependent DNA polymerase, blocking its function in viral DNA replication. In combination with other antiretroviral drugs, this agent has been shown to significantly reduce HIV viral load, retarding or preventing damage to the immune system and reducing the risk of developing AIDS. Efavirenz induces activity of the cytochrome P450 system, accelerating its own metabolism.

NCI-GLOSS Definition: A drug used with other drugs to treat infection with the human immunodeficiency virus (HIV). It blocks HIV from making copies of itself. It is a type of non-nucleoside reverse transcriptase inhibitor and a type of antiviral agent.

Display Name: Efavirenz

Label: Efavirenz

NCI Thesaurus Code: C29027 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0674428  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 154598-52-4 (see NLM ChemIDplus info)
ChEBI ID CHEBI:119486 (see ChEBI info)
PDQ Closed Trial Search ID 540650
PDQ Open Trial Search ID 540650 (check for NCI PDQ open clinical trial info)
UMLS CUI C0674428

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C14H9ClF3NO2
code C29027
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Efavirenz
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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