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Version: 17.06d (Release date: 2017-06-26)
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Digoxin (Code C28990)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Digoxin

Definition: A cardiac glycoside. Digoxin inhibits the sodium potassium adenosine triphosphatase (ATPase) pump, thereby increasing intracellular calcium and enhancing cardiac contractility. This agent also acts directly on the atrioventricular node to suppress conduction, thereby slowing conduction velocity. Apparently due to its effects on intracellular calcium concentrations, digoxin induces apoptosis of tumor cells via a pathway involving mitochondrial cytochrome c and caspases 8 and 3. (NCI04)

NCI-GLOSS Definition: A drug used to treat irregular heartbeat and some types of heart failure. It is also being studied in the treatment of some types of cancer. Digoxin helps the heart work normally by controlling the amount of calcium that goes into the heart muscle. It also may kill cancer cells and make them more sensitive to anticancer drugs. It is a type of cardiac glycoside.

Display Name: Digoxin

Label: Digoxin

NCI Thesaurus Code: C28990 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0012265  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
12beta-Hydroxydigitoxin
3beta,12beta,14-Trihydroxy-5beta,14beta-card-20(22)-enolid-3-tridigitoxosid
Cardiogoxin
Digoxigenin-tridigitoxosid
Digoxin
DIGOXIN
digoxin
Lanoxin

External Source Codes: 
CAS Registry Number 20830-75-5 (see NLM ChemIDplus info)
FDA UNII Code 73K4184T59
ChEBI ID CHEBI:4551 (see ChEBI info)
NSC Code 95100 (see NCI DTP info)
PDQ Closed Trial Search ID 485249
PDQ Open Trial Search ID 485249 (check for NCI PDQ open clinical trial info)
UMLS CUI C0012265

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C41H64O14
code C28990
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Digoxin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28990

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