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Version: 17.06d (Release date: 2017-06-26)
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Desipramine Hydrochloride (Code C28979)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Desipramine Hydrochloride

Definition: The hydrochloride salt form of desipramine, a secondary amine tricyclic antidepressant (TCA). In the central nervous system (CNS), desipramine hydrochloride blocks the re-uptake of neurotransmitters, including norepinephrine and serotonin. This leads to an increase in the amount of these neurotransmitters in the synaptic cleft and prolongs their activities postsynaptically.

Display Name: Desipramine Hydrochloride

Label: Desipramine Hydrochloride

NCI Thesaurus Code: C28979 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0031232  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Desipramine Hydrochloride
DESIPRAMINE HYDROCHLORIDE
Norpramin
Pertofrane

External Source Codes: 
CAS Registry Number 58-28-6 (see NLM ChemIDplus info)
FDA UNII Code 1Y58DO4MY1
ChEBI ID CHEBI:4449 (see ChEBI info)
NSC Code 114901 (see NCI DTP info)
PDQ Closed Trial Search ID 742241
PDQ Open Trial Search ID 742241 (check for NCI PDQ open clinical trial info)
UMLS CUI C0031232

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C18H22N2.HCl
code C28979
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Desipramine_Hydrochloride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28979

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