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Version: 17.06d (Release date: 2017-06-26)
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Demeclocycline Hydrochloride (Code C28975)

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Terms & Properties

Preferred Name: Demeclocycline Hydrochloride

Definition: The hydrochloride salt of demeclocycline, a broad-spectrum, tetracycline derivative exhibiting antimicrobial, aquaretic and chelating activities. In bacteria, demeclocycline binds reversibly to the 30S ribosomal subunit and blocks the binding of aminoacyl-tRNA to the A-site of the mRNA-ribosome complex, resulting in the inhibition of protein synthesis and bacterial cell death. In mammals, this agent interferes with the action of antidiuretic hormone (ADH) at the level of the renal collecting tubule, resulting in aquaresis. In addition, demeclocycline, which like other tetracyclines chelates calcium in bone and exhibits a yellow fluorescence under ultraviolet (UV) light, may be used as a fluorescent bone-labeling agent in bone histomorphometry.

NCI-GLOSS Definition: A substance being studied as a way to detect bone growth in patients receiving bisphosphonates (a type of drug used to treat bone pain caused by some types of cancer) for breast cancer. It binds to newly formed bone. A biopsy is done and bone growth is measured using a special microscope. Declomycin is a type of tetracycline antibiotic and a type of bone-labeling agent.

Display Name: Demeclocycline Hydrochloride

Label: Demeclocycline Hydrochloride

NCI Thesaurus Code: C28975 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0282125  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide Monohydrochloride
Declomycin
Demeclocycline Hydrochloride
DEMECLOCYCLINE HYDROCHLORIDE
demeclocycline hydrochloride

External Source Codes: 
CAS Registry Number 64-73-3 (see NLM ChemIDplus info)
FDA UNII Code 29O079NTYT
ChEBI ID CHEBI:59725 (see ChEBI info)
PDQ Closed Trial Search ID 659335
PDQ Open Trial Search ID 659335 (check for NCI PDQ open clinical trial info)
UMLS CUI C0282125

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C21H21ClN2O8.HCl
code C28975
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Demeclocycline_Hydrochloride
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28975

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