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Version: 17.06d (Release date: 2017-06-26)
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Diacetylmorphine Hydrochloride (Code C28958)

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Terms & Properties

Preferred Name: Diacetylmorphine Hydrochloride

Definition: The hydrochloride salt of a diacetyl derivative of the opiate morphine, a naturally occurring alkaloid extracted from the seedpod of the Asian poppy (Papaver sp.). Once administered, diamorphine (or diacetylmorphine) is rapidly hydrolyzed to 6-monoacetylmorphine (6-MAM) and then to the end-product morphine which binds to opiate receptors located throughout the mammalian nervous and gastrointestinal systems. Inducing a potent analgesia, the use of diamoprhine is often escalated due to a tolerance effect, resulting in abuse that is associated with fatal overdose, abortion, venous sclerosis, and opportunistic infections, among other adverse effects. (NCI04)

Label: Diacetylmorphine Hydrochloride

NCI Thesaurus Code: C28958 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0282128  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Diacetylmorphine Hydrochloride
DIACETYLMORPHINE HYDROCHLORIDE
Diamorphine Hydrochloride
Heroine Hydrochloride
Heroin Hydrochloride
Morphinan-3,6alpha-diol, 7,8-didehydro-4,5alpha-epoxy-17-methyl-, Morphine, Diacetate (ester), Hydrochloride

External Source Codes: 
CAS Registry Number 1502-95-0 (see NLM ChemIDplus info)
FDA UNII Code 8H672SHT8E
NSC Code 302357 (see NCI DTP info)
UMLS CUI C0282128

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C21H23NO5.HCl
code C28958
Contributing_Source FDA
Legacy_Concept_Name Diamorphine_Hydrochloride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28958

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