skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Cyproheptadine Hydrochloride (Code C28949)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Cyproheptadine Hydrochloride

Definition: The hydrochloride salt of a synthetic methyl-piperidine derivative with antihistaminic and anti-serotoninergic properties. Cyproheptadine competes with free histamine (HA) for binding at HA-receptor sites, thereby competitively antagonizing histamine stimulation of HA-receptors in the gastrointestinal tract, large blood vessels, and bronchial smooth muscle. This agent also competes with free serotonin for binding at serotonin receptor sites. Cyproheptadine exhibits anticholinergic and sedative properties and has been shown to stimulate appetite and weight gain. (NCI04)

Display Name: Cyproheptadine Hydrochloride

Label: Cyproheptadine Hydrochloride

NCI Thesaurus Code: C28949 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0354872  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine Hydrochloride Sesquihydrate
Cyproheptadine Hydrochloride
CYPROHEPTADINE HYDROCHLORIDE
Periactin

External Source Codes: 
CAS Registry Number 41354-29-4 (see NLM ChemIDplus info)
FDA UNII Code NJ82J0F8QC
ChEBI ID CHEBI:59695 (see ChEBI info)
ChEBI ID CHEBI:650917 (see ChEBI info)
NSC Code 169911 (see NCI DTP info)
PDQ Closed Trial Search ID 315774
PDQ Open Trial Search ID 315774 (check for NCI PDQ open clinical trial info)
UMLS CUI C0354872

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Hypersensitivity reactions
Chemical_Formula 2C21H21N.2HCl.3H2O
code C28949
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Cyproheptadine_Hydrochloride
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28949

Mainbox Bottom