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Version: 17.06d (Release date: 2017-06-26)
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Chlorzoxazone (Code C28926)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Chlorzoxazone

Definition: A benzoxazolone derivative with mild sedative and centrally-acting muscle relaxant activities. Although its exact mechanism of action is unknown, chlorzoxazone (CZ) appears to act at the spinal cord and subcortical levels of the brain to inhibit multisynaptic reflex arcs involved in producing and maintaining muscle spasms. This agent is extensively hydroxylated by cytochrome P450 2E1 (CYP2E1) to 6-hydroxychlorzoxazone (HCZ),11,12 which is subsequently glucuronidated and eliminated renally. Highly selective for CYP2E1, CZ may be used as a selective probe for phenotyping CYP2E1 in humans; the ratio of HCZ-to-CZ plasma concentrations obtained 2 to 4 hours after oral administration of CZ may be used as a phenotypic measure of CYP2E1 enzymatic activity.

Label: Chlorzoxazone

NCI Thesaurus Code: C28926 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0008296  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CHLORZOXAZONE
Chlorzoxazone
Paraflex

External Source Codes: 
CAS Registry Number 95-25-0 (see NLM ChemIDplus info)
FDA UNII Code H0DE420U8G
ChEBI ID CHEBI:3655 (see ChEBI info)
NSC Code 26189 (see NCI DTP info)
PDQ Closed Trial Search ID 577391
PDQ Open Trial Search ID 577391 (check for NCI PDQ open clinical trial info)
UMLS CUI C0008296

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C7H4ClNO2
code C28926
Contributing_Source FDA
Legacy_Concept_Name Chlorzoxazone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28926

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