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Version: 17.06d (Release date: 2017-06-26)
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Cefpodoxime Proxetil (Code C28916)

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Terms & Properties

Preferred Name: Cefpodoxime Proxetil

Definition: A third generation semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefpodoxime's effect is dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in the inhibition of the transpeptidase enzymes, thereby preventing cross-linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidoglycan chains. As a result, cefpodoxime inhibits bacterial septum and cell wall synthesis formation.

Display Name: Cefpodoxime Proxetil

Label: Cefpodoxime Proxetil

NCI Thesaurus Code: C28916 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0108938  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cefpodoxime Proxetil

External Source Codes: 
CAS Registry Number 87239-81-4 (see NLM ChemIDplus info)
ChEBI ID CHEBI:3505 (see ChEBI info)
PDQ Closed Trial Search ID 455227
PDQ Open Trial Search ID 455227 (check for NCI PDQ open clinical trial info)
UMLS CUI C0108938

Other Properties:
     Name Value (qualifiers indented underneath)
code C28916
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Cefpodoxime
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  


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