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Version: 17.06d (Release date: 2017-06-26)
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Candesartan Cilexetil (Code C28903)

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Terms & Properties

Preferred Name: Candesartan Cilexetil

Definition: A synthetic, benzimidazole-derived angiotensin II receptor antagonist prodrug with antihypertensive activity. After hydrolysis of candesartan cilexetil to candesartan during gastrointestinal absorption, candesartan selectively competes with angiotensin II for the binding of the angiotensin II receptor subtype 1 (AT1) in vascular smooth muscle, blocking angiotensin II-mediated vasoconstriction and inducing vasodilatation. In addition, antagonism of AT1 in the adrenal gland inhibits angiotensin II-stimulated aldosterone synthesis and secretion by the adrenal cortex; sodium and water excretion increase, followed by a reduction in plasma volume and blood pressure.

Label: Candesartan Cilexetil

NCI Thesaurus Code: C28903 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0527379  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Candesartan Cilexetil

External Source Codes: 
CAS Registry Number 145040-37-5 (see NLM ChemIDplus info)
FDA UNII Code R85M2X0D68
PDQ Closed Trial Search ID 546971
PDQ Open Trial Search ID 546971 (check for NCI PDQ open clinical trial info)
UMLS CUI C0527379

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C33H34N6O6
code C28903
Contributing_Source FDA
Legacy_Concept_Name Candesartan_Cilexetil
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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