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Version: 17.06d (Release date: 2017-06-26)
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Abatacept (Code C28898)

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Terms & Properties

Preferred Name: Abatacept

Definition: A soluble fusion protein consisting of the extracellular domain of human cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) linked to a modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1) with immunosuppressive activity. Abatacept binds CD80 and CD86 on antigen presenting cells (APCs), blocking interaction with CD28 on T lymphocytes, which initiates a co-stimulatory signal required for full activation of T lymphocytes.

Display Name: Abatacept

Label: Abatacept

NCI Thesaurus Code: C28898 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1619966  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Abatacept
ABATACEPT
BMS-188667
CTLA4-Ig
CTL A4-Ig B7 Inhibitor
cytotoxic T lymphocyte-associated antigen-4
Orencia
RG2077

External Source Codes: 
CAS Registry Number 332348-12-6 (see NLM ChemIDplus info)
FDA UNII Code 7D0YB67S97
NSC Code 710084 (see NCI DTP info)
PDQ Closed Trial Search ID 660119
PDQ Open Trial Search ID 660119 (check for NCI PDQ open clinical trial info)
UMLS CUI C1619966

Other Properties:
     Name Value (qualifiers indented underneath)
code C28898
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name CTLA4-Ig
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28898

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