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Version: 17.06d (Release date: 2017-06-26)
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Bupivacaine Hydrochloride (Code C28876)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Bupivacaine Hydrochloride

Definition: A long-acting, amide-type local anesthetic. Bupivicaine reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the voltage-dependent membrane permeability to sodium ions and membrane stabilization; inhibition of depolarization and nerve impulse conduction; and a reversible loss of sensation.

NCI-GLOSS Definition: A drug used to relieve pain by blocking signals at nerve endings. It is being studied in the relief of pain following surgery for cancer. It is a type of local anesthetic.

Display Name: Bupivacaine Hydrochloride

Label: Bupivacaine Hydrochloride

NCI Thesaurus Code: C28876 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0887621  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Bupivacaine Hydrochloride
BUPIVACAINE HYDROCHLORIDE
bupivacaine hydrochloride
Marcain
Marcaine
Sensorcaine

External Source Codes: 
CAS Registry Number 73360-54-0 (see NLM ChemIDplus info)
FDA UNII Code 7TQO7W3VT8
ChEBI ID CHEBI:31322 (see ChEBI info)
ChEBI ID CHEBI:60789 (see ChEBI info)
PDQ Closed Trial Search ID 481366
PDQ Open Trial Search ID 481366 (check for NCI PDQ open clinical trial info)
UMLS CUI C0887621

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C18H28N2O.HCl.H2O
code C28876
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Bupivacaine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28876

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