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Version: 17.08d (Release date: 2017-08-28)
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Bisoprolol Fumarate (Code C28871)

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Terms & Properties

Preferred Name: Bisoprolol Fumarate

Definition: The fumarate salt of a synthetic phenoxy-2-propanol-derived cardioselective beta-1 adrenergic receptor antagonist with antihypertensive and potential cardioprotective activities. Devoid of intrinsic sympathomimetic activity, bisoprolol selectively and competitively binds to and blocks beta-1 adrenergic receptors in the heart, decreasing cardiac contractility and rate, reducing cardiac output, and lowering blood pressure. In addition, this agent may exhibit antihypertensive activity through the inhibition of renin secretion by juxtaglomerular epithelioid (JGE) cells in the kidney, thus inhibiting activation of the renin-angiotensin system (RAS). Bisoprolol has been shown to be cardioprotective in animal models.

Label: Bisoprolol Fumarate

NCI Thesaurus Code: C28871 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0543473  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(+-)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol fumarate (2:1) (salt)
Bisoprolol Fumarate
Bisoprolol Hemifumarate

External Source Codes: 
CAS Registry Number 104344-23-2 (see NLM ChemIDplus info)
ChEBI ID CHEBI:3128 (see ChEBI info)
PDQ Closed Trial Search ID 660819
PDQ Open Trial Search ID 660819 (check for NCI PDQ open clinical trial info)
UMLS CUI C0543473

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula 2C18H31NO4.C4H4O4
code C28871
Contributing_Source FDA
Legacy_Concept_Name Bisoprolol_Fumarate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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