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Version: 17.12d (Release date: 2017-12-26)
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Benazepril Hydrochloride (Code C28862)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Benazepril Hydrochloride

Definition: The hydrochloride salt of benazepril, a carboxyl-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, benazepril is metabolized to its active form benazeprilat. Benazeprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Benazeprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.

Display Name: Benazepril Hydrochloride

Label: Benazepril Hydrochloride

NCI Thesaurus Code: C28862 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0770917  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Benazepril HCl
Benazepril Hydrochloride

External Source Codes: 
CAS Registry Number 86541-74-4 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 686949
PDQ Open Trial Search ID 686949 (check for NCI PDQ open clinical trial info)
UMLS CUI C0770917

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C24H28N2O5.ClH
code C28862
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Benazepril_Hydrochloride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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