skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Benazepril Hydrochloride (Code C28862)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Benazepril Hydrochloride

Definition: The hydrochloride salt of benazepril, a carboxyl-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, benazepril is metabolized to its active form benazeprilat. Benazeprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Benazeprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.

Display Name: Benazepril Hydrochloride

Label: Benazepril Hydrochloride

NCI Thesaurus Code: C28862 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0770917  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Benazepril HCl
Benazepril Hydrochloride
BENAZEPRIL HYDROCHLORIDE
CGS14824A
Lotensin

External Source Codes: 
CAS Registry Number 86541-74-4 (see NLM ChemIDplus info)
FDA UNII Code N1SN99T69T
PDQ Closed Trial Search ID 686949
PDQ Open Trial Search ID 686949 (check for NCI PDQ open clinical trial info)
UMLS CUI C0770917

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C24H28N2O5.ClH
code C28862
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Benazepril_Hydrochloride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28862

Mainbox Bottom