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Version: 16.11d (Release date: 2016-11-28)
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Baclofen (Code C28858)

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Terms & Properties

Preferred Name: Baclofen

Definition: A synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen acts as a gamma-aminobutyric acid (GABA) agonist specific for GABA-B receptors. It acts at spinal and supraspinal sites, reducing excitatory transmission. (NCI04)

NCI-GLOSS Definition: A drug that is used to treat certain types of muscle spasms and is being studied in the treatment of liver cancer. Baclofen relaxes muscles by blocking certain nerve receptors in the spinal cord. It is a type of antispasmodic.

Label: Baclofen

NCI Thesaurus Code: C28858 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0699999  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-Amino-3-(4-chlorophenyl)-butanoic Acid
BA34647
BACLOFEN
Baclofen
baclofen
beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid
Gablofen
Kemstro
Lioresal

External Source Codes: 
CAS Registry Number 1134-47-0 (see NLM ChemIDplus info)
FDA UNII Code H789N3FKE8
ChEBI ID CHEBI:2972 (see ChEBI info)
NSC Code 329137 (see NCI DTP info)
PDQ Closed Trial Search ID 560777
PDQ Open Trial Search ID 560777 (check for NCI PDQ open clinical trial info)
UMLS CUI C0699999

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Cerebral Spasticity, Chronic Spasticity
Chemical_Formula C10H12ClNO2
code C28858
Contributing_Source FDA
Legacy_Concept_Name Baclofen
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28858

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