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Version: 17.06d (Release date: 2017-06-26)
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Azithromycin (Code C28844)

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Terms & Properties

Preferred Name: Azithromycin

Definition: An azalide, derived from erythromycin, and a member of a subclass of macrolide antibiotics with bacteriocidal and bacteriostatic activities. Azithromycin reversibly binds to the 50S ribosomal subunit of the 70S ribosome of sensitive microorganisms, thereby inhibiting the translocation step of protein synthesis, wherein a newly synthesized peptidyl tRNA molecule moves from the acceptor site on the ribosome to the peptidyl (donor) site, and consequently inhibiting RNA-dependent protein synthesis leading to cell growth inhibition and cell death.

Display Name: Azithromycin

Label: Azithromycin

NCI Thesaurus Code: C28844 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0678143  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[(3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy]-1-oxa-6-azacyclopentade
AzaSite
Azithromycin
AZITHROMYCIN, UNSPECIFIED FORM
CP 62993
N-methyl-11-aza-10-deoxy-10-dihydroerythromycin A
XZ-450
Zithromax

External Source Codes: 
CAS Registry Number 83905-01-5 (see NLM ChemIDplus info)
FDA UNII Code F94OW58Y8V
NSC Code 643732 (see NCI DTP info)
PDQ Closed Trial Search ID 695416
PDQ Open Trial Search ID 695416 (check for NCI PDQ open clinical trial info)
UMLS CUI C0678143

Other Properties:
     Name Value (qualifiers indented underneath)
code C28844
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Azithromycin
Semantic_Type Antibiotic

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28844

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