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Version: 17.06d (Release date: 2017-06-26)
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Atorvastatin Calcium (Code C28837)

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Terms & Properties

Preferred Name: Atorvastatin Calcium

Definition: The calcium salt of atorvastatin, a synthetic lipid-lowering agent. Atorvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent increases the number of LDL receptors on hepatic cell surfaces, enhancing the uptake and catabolism of LDL and reducing LDL production and the number of LDL particles, and lowers plasma cholesterol and lipoprotein levels. Like other statins, atorvastatin may also display direct antineoplastic activity, possibly by inhibiting farnesylation and geranylgeranylation of proteins such as small GTP-binding proteins, which may result in the arrest of cells in the G1 phase of the cell cycle. This agent may also sensitize tumor cells to cyctostatic drugs, possibly through the mTOR-dependent inhibition of Akt phosphorylation.

NCI-GLOSS Definition: A drug used to lower the amount of cholesterol in the blood and to prevent stroke, heart attack, and angina (chest pain). It is also being studied in the prevention and treatment of some types of cancer and other conditions. Atorvastatin calcium blocks an enzyme that helps make cholesterol in the body. It also causes an increase in the breakdown of cholesterol. It is a type of HMG-CoA reductase inhibitor and a type of statin.

Display Name: Atorvastatin Calcium

Label: Atorvastatin Calcium

NCI Thesaurus Code: C28837 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0286650  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Atorvastatin Calcium
atorvastatin calcium
ATORVASTATIN CALCIUM
CI-981
Lipitor

External Source Codes: 
CAS Registry Number 134523-03-8 (see NLM ChemIDplus info)
CAS Registry Number 344423-98-9 (see NLM ChemIDplus info)
FDA UNII Code 48A5M73Z4Q
ChEBI ID CHEBI:2911 (see ChEBI info)
PDQ Closed Trial Search ID 460239
PDQ Open Trial Search ID 460239 (check for NCI PDQ open clinical trial info)
UMLS CUI C0286650

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula 2C33H34FN2O5.Ca.3H2O
code C28837
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Atorvastatin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28837

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