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Version: 17.06d (Release date: 2017-06-26)
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Anagrelide Hydrochloride (Code C28826)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Anagrelide Hydrochloride

Definition: The hydrochloride salt of a synthetic quinazoline derivative, Anagrelide Hydrochloride reduces platelet production through a decrease in megakaryocyte maturation. Anagrelide inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation. At therapeutic doses, it does not influence white cell counts or coagulation parameters. Anagrelide is used for treatment of essential thrombocythemia to reduce elevated platelet counts and the risk of thrombosis. (NCI04)

Label: Anagrelide Hydrochloride

NCI Thesaurus Code: C28826 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0771907  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Agrylin
Anagrelide Hydrochloride
ANAGRELIDE HYDROCHLORIDE

External Source Codes: 
CAS Registry Number 58579-51-4 (see NLM ChemIDplus info)
FDA UNII Code VNS4435G39
ChEBI ID CHEBI:55345 (see ChEBI info)
NSC Code 724577 (see NCI DTP info)
UMLS CUI C0771907

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C10H7Cl2N3O.ClH
code C28826
Contributing_Source FDA
Legacy_Concept_Name Anagrelide_Hydrochloride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28826

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