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Version: 17.06d (Release date: 2017-06-26)
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Ampicillin Sodium/Sulbactam Sodium (Code C28823)

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Terms & Properties

Preferred Name: Ampicillin Sodium/Sulbactam Sodium

Definition: A combination formulation of the sodium salts of the antibiotic ampicillin and the beta-lactamase inhibitor sulbactam with antibacterial activity. Ampicillin, a broad-spectrum, semisynthetic penicillin, binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall, thereby interfering with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. As a result, the cell wall is weakened and the cell lyses. The sulbactam component irreversibly binds to bacterial beta-lactamase at or near its active site, thereby interfering with substrate binding and inhibiting bacterial metabolism of penicillin and cephalosporin beta-lactam antibiotics, effectively extending their antibiotic spectrum to include many beta-lactam-resistant bacteria.

Label: Ampicillin Sodium/Sulbactam Sodium

NCI Thesaurus Code: C28823 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0147814  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ampicillin Sodium/Sulbactam Sodium
Unasyn

External Source Codes: 
PDQ Closed Trial Search ID 500377
PDQ Open Trial Search ID 500377 (check for NCI PDQ open clinical trial info)
UMLS CUI C0147814

Other Properties:
     Name Value (qualifiers indented underneath)
code C28823
Legacy_Concept_Name Ampicillin_Sodium-Sulbactam_Sodium
Semantic_Type Antibiotic

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28823

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