skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Alprostadil (Code C28816)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Alprostadil

Definition: The naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Alprostadil is a potent vasodilator agent that increases peripheral blood flow, inhibits platelet aggregation, and induces bronchodilation. Used in the treatment of erectile dysfunction, this agent produces corporal smooth muscle relaxation by binding to PGE receptors, resulting in the activation of adenylate cyclase and the subsequent accumulation of 3'5'-cAMP.

NCI-GLOSS Definition: A drug that is used to treat impotence (inability to have an erection) and is being studied in the treatment of sexual problems in men who have had surgery for prostate cancer. It is a type of vasodilator.

Display Name: Alprostadil

Label: Alprostadil

NCI Thesaurus Code: C28816 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0002335  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic Acid
Muse (intraurethral alprostadil suppository)
prostaglandin E1
Prostaglandin E1

External Source Codes: 
CAS Registry Number 745-65-3 (see NLM ChemIDplus info)
FDA UNII Code F5TD010360
ChEBI ID CHEBI:15544 (see ChEBI info)
NSC Code 165559 (see NCI DTP info)
PDQ Closed Trial Search ID 360459
PDQ Open Trial Search ID 360459 (check for NCI PDQ open clinical trial info)
UMLS CUI C0002335

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Erectile dysfunction; Patent ductus arteriosus
Chemical_Formula C20H34O5
code C28816
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Alprostadil
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


Mainbox Bottom