skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Azacitidine (Code C288)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Azacitidine

Definition: A pyrimidine nucleoside analogue of cytidine with antineoplastic activity. Azacitidine is incorporated into DNA, where it reversibly inhibits DNA methyltransferase, thereby blocking DNA methylation. Hypomethylation of DNA by azacitidine may activate tumor suppressor genes silenced by hypermethylation, resulting in an antitumor effect. This agent is also incorporated into RNA, thereby disrupting normal RNA function and impairing tRNA cytosine-5-methyltransferase activity. (NCI04)

NCI-GLOSS Definition: A drug that is used to treat myelodysplastic syndromes and is being studied in the treatment of other types of cancer. It belongs to the family of drugs called antimetabolites.

Display Name: Azacitidine

Label: Azacitidine

NCI Thesaurus Code: C288 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0004475  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-Amino-1-beta-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
5-AC
5-Aza-cytidine
5-Azacytidine
5-AZC
5 AZC
Azacitidine
AZACITIDINE
azacitidine
Azacytidine
Azacytidine, 5-
Ladakamycin
Mylosar
U-18496
Vidaza

External Source Codes: 
CAS Registry Number 320-67-2 (see NLM ChemIDplus info)
FDA UNII Code M801H13NRU
ChEBI ID CHEBI:2038 (see ChEBI info)
NSC Code 102816 (see NCI DTP info)
PDQ Closed Trial Search ID 39153
PDQ Open Trial Search ID 39153 (check for NCI PDQ open clinical trial info)
UMLS CUI C0004475

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Myelodysplastic Syndrome
Chemical_Formula C8H12N4O5
code C288
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Azacitidine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C288

Mainbox Bottom