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Version: 16.11d (Release date: 2016-11-28)
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MART-1 Antigen (Code C28724)

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Terms & Properties

Preferred Name: MART-1 Antigen

Definition: A tumor-associated melanocytic differentiation antigen. Vaccination with MART-1 antigen may stimulate a host cytotoxic T-cell response against tumor cells expressing the melanocytic differentiation antigen, resulting in tumor cell lysis. (NCI04)

NCI-GLOSS Definition: A protein found on normal melanocytes (cells that make the pigment melanin) in the skin and in the retina. It is also found on most melanomas (cancers that begin in melanocytes). Vaccines using pieces of the MART-1 antigen are being studied for their ability to boost the immune response to cancer cells in patients with melanoma.

Display Name: MART-1 Antigen

Label: MART-1 Antigen

NCI Thesaurus Code: C28724 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1522481  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Antigen LB39-AA
Antigen SK29-AA
MART-1
MART-1 Antigen
MART-1 antigen
MART-1 Tumor Antigen
MART1
Melan-A
Melan-A Protein
Melanoma Antigen Recognized by T-Cells 1
Melan A
MLANA
MLANA Protein

External Source Codes: 
PDQ Closed Trial Search ID 42205
PDQ Open Trial Search ID 42205 (check for NCI PDQ open clinical trial info)
UMLS CUI C1522481

Other Properties:
Name Value (qualifiers indented underneath)
code C28724
Contributing_Source CTRP
Legacy_Concept_Name MART-1_Antigen
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28724

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