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Version: 17.06d (Release date: 2017-06-26)
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Recombinant 70-kD Heat-Shock Protein (Code C28696)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Recombinant 70-kD Heat-Shock Protein

Definition: A recombinant peptide that is chemically identical to or similar to the endogenous 70-kD heat shock protein (HSP70). HSP70 is a molecular chaperone that prevents physiologic stress-induced cell death by inhibiting both caspase-dependent and caspase-independent apoptosis. Because this peptide is often overexpressed in tumor cells, autologous vaccination with HSP70 derived from tumor cells may stimulate the host immune system to mount a tumoricidal cytotoxic T lymphocyte (CTL) response. (NCI04)

Label: Recombinant 70-kD Heat-Shock Protein

NCI Thesaurus Code: C28696 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1527149  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
70-kD Heat-Shock Protein
Heat Shock Protein 70
HSP70
Recombinant 70-kD Heat-Shock Protein

External Source Codes: 
PDQ Closed Trial Search ID 37945
PDQ Open Trial Search ID 37945 (check for NCI PDQ open clinical trial info)
UMLS CUI C1527149

Other Properties:
     Name Value (qualifiers indented underneath)
code C28696
Legacy_Concept_Name Therapeutic_70-kD_Heat-Shock_Protein
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28696

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