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Version: 16.11d (Release date: 2016-11-28)
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Asparaginase (Code C286)

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Terms & Properties

Preferred Name: Asparaginase

Definition: An enzyme isolated from the bacterium Escherichia coli or the bacterium Erwinia carotovora with antileukemic activity. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia in leukemic cells, resulting in the depletion of asparagine, inhibition of protein synthesis, cell cycle arrest in the G1 phase, and apoptosis in susceptible leukemic cell populations. Asparagine is critical to protein synthesis in leukemic cells; some leukemic cells cannot synthesize this amino acid de novo due to the absent or deficient expression of the enzyme asparagine synthase. The E. carotovora-derived form of asparaginase is typically reserved for cases of asparaginase hypersensitivity.

NCI-GLOSS Definition: A drug that is used to treat acute lymphoblastic leukemia (ALL) and is being studied in the treatment of some other types of cancer. It is an enzyme taken from the bacterium Escherichia coli (E. coli). It breaks down the amino acid asparagine and may block the growth of tumor cells that need asparagine to grow.

Display Name: Asparaginase

Label: Asparaginase

NCI Thesaurus Code: C286 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0003993  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ASP-1
Asparaginase
ASPARAGINASE
asparaginase
Asparaginase-E.Coli
Asparaginase II
Colaspase
Elspar
Kidrolase
L-Asnase
L-ASP
L-Asparaginase
L-asparaginase
L-Asparagine Amidohydrolase
L-Asparagine amidohydrolase
Laspar
Lcf-ASP
Leucogen
Leunase
MK-965
Paronal
Re-82-TAD-15
Serasa

External Source Codes: 
CAS Registry Number 9015-68-3 (see NLM ChemIDplus info)
FDA UNII Code G4FQ3CKY5R
NSC Code 109229 (see NCI DTP info)
PDQ Closed Trial Search ID 41146
PDQ Open Trial Search ID 41146 (check for NCI PDQ open clinical trial info)
UMLS CUI C0003993

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Acute lymphocytic leukemia; Acute non-lymphocytic leukemia
code C286
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Asparaginase
Semantic_Type Enzyme
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C286

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