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National Cancer Institute
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Version: 17.10e (Release date: 2017-10-30)
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ONYX-015 (Code C2830)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: ONYX-015

Definition: An E1B-55kDa-deleted adenovirus that is able to selectively replicate in and lyse TP53-deficient human tumor cells. After tumor cell lysis, released viruses infect neighboring tumor cells, tripping a chain of ONYX-015-mediated tumor cell cytotoxicity. (NCI04)

NCI-GLOSS Definition: A modified cold virus that selectively grows in and destroys certain types of cancer cells and leaves normal cells undamaged.

Label: ONYX-015

NCI Thesaurus Code: C2830 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0678040  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
E1B 55kDa mutant adenovirus dl1520
E1B-Attenuated Adenovirus

External Source Codes: 
NSC Code 688653 (see NCI DTP info)
PDQ Closed Trial Search ID 43035
PDQ Open Trial Search ID 43035 (check for NCI PDQ open clinical trial info)
UMLS CUI C0678040

Other Properties:
     Name Value (qualifiers indented underneath)
code C2830
Legacy_Concept_Name ONYX-015
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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