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Version: 17.06d (Release date: 2017-06-26)
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Topotecan Hydrochloride (Code C2828)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Topotecan Hydrochloride

Definition: The hydrochloride salt of a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata.

NCI-GLOSS Definition: A drug used to treat certain types of ovarian cancer, lung cancer, and cervical cancer. Hycamtin is a type of topoisomerase inhibitor.

Display Name: Topotecan Hydrochloride

Label: Topotecan Hydrochloride

NCI Thesaurus Code: C2828 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0886549  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7] indolizino[1,2-b] quinoline-3,14-(4H,12H)-dione Monohydrochloride
Hycamptamine
Hycamtin
SKF S-104864-A
Topotecan HCl
Topotecan Hydrochloride
TOPOTECAN HYDROCHLORIDE
Topotecan hydrochloride
topotecan hydrochloride
topotecan hydrochloride (oral)

External Source Codes: 
CAS Registry Number 119413-54-6 (see NLM ChemIDplus info)
FDA UNII Code 956S425ZCY
NSC Code 609699 (see NCI DTP info)
PDQ Closed Trial Search ID 41185
PDQ Open Trial Search ID 41185 (check for NCI PDQ open clinical trial info)
UMLS CUI C0886549

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Small Cell Lung Carcinoma; Cervical Cancer
Chemical_Formula C23H23N3O5.HCl
code C2828
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Topotecan_Hydrochloride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2828

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