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Version: 17.06d (Release date: 2017-06-26)
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Racemic XK469 (Code C2825)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Racemic XK469

Definition: The racemic form of a synthetic quinoxaline phenoxypropionic acid derivative with antineoplastic properties. XK469R selectively inhibits topoisomerase II by stabilizing the enzyme-DNA intermediates in which topoisomerase subunits are covalently linked to DNA through 5-phosphotyrosyl linkages, thereby interfering with DNA repair and replication, RNA and protein synthesis. This agent possesses unusual solid tumor selectivity and activity against multidrug-resistant cancer cells. XK469R is more water soluble and active than the pure isomers, R(+)XK469 and S(-)XK469. (NCI05)

Label: Racemic XK469

NCI Thesaurus Code: C2825 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1611867  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Propanoic acid, 2-[4-[(7-chloro-2-quinoxalinyl)oxy]-phenoxy]-, (+ /-)-
Racemic XK469
XK469R
XK469 Racemic

External Source Codes: 
CAS Registry Number 157542-91-1 (see NLM ChemIDplus info)
NSC Code 698215 (see NCI DTP info)
PDQ Closed Trial Search ID 440966
PDQ Open Trial Search ID 440966 (check for NCI PDQ open clinical trial info)
UMLS CUI C1611867

Other Properties:
     Name Value (qualifiers indented underneath)
code C2825
Legacy_Concept_Name XK469R
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2825

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