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Version: 17.12d (Release date: 2017-12-26)
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Valacyclovir (Code C28235)

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Terms & Properties

Preferred Name: Valacyclovir

Definition: The hydrochloride salt of the L-valyl ester of the antiviral drug acyclovir. Orally administered, valacyclovir is rapidly converted to acyclovir which inhibits viral DNA replication after further conversion to the nucleotide analog acyclovir triphosphate by viral thymidine kinase, cellular guanyl cyclase, and a number of other cellular enzymes. Acyclovir triphosphate competitively inhibits viral DNA polymerase; incorporates into and terminates the growing viral DNA chain; and inactivates viral DNA polymerase. The greater antiviral activity of acyclovir against herpes simplex virus (HSV) compared with varicella-zoster virus (VZV) is due to its more efficient phosphorylation by HSV thymidine kinase.

NCI-GLOSS Definition: A substance that is being studied in the prevention of fungal, bacterial, and viral infections in patients undergoing donor stem cell transplantation with cells that are infected with cytomegalovirus. It belongs to the family of drugs called antivirals.

Display Name: Valacyclovir

Label: Valacyclovir

NCI Thesaurus Code: C28235 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0249458  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
L-Valine ester with 9-((2-hydroxyethoxy)methyl)guanine

External Source Codes: 
CAS Registry Number 124832-26-4 (see NLM ChemIDplus info)
ChEBI ID CHEBI:35854 (see ChEBI info)
PDQ Closed Trial Search ID 257236
PDQ Open Trial Search ID 257236 (check for NCI PDQ open clinical trial info)
UMLS CUI C0249458

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C13H20N6O4
code C28235
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Valacyclovir
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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