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Version: 17.06d (Release date: 2017-06-26)
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Bromelains (Code C28134)

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Terms & Properties

Preferred Name: Bromelains

Definition: A proteolytic enzyme obtained from the pineapple plant that cleaves sulfhydryl groups. The enzyme is adsorbed intact through the gastrointestinal tract and has demonstrated therapeutic benefit. Bromelain has the ability to modulate cytokines, and has also demonstrated anti-inflammatory activity, immune response activity, and fibrinolytic activity.

NCI-GLOSS Definition: An enzyme found in pineapples that breaks down other proteins, such as collagen and muscle fiber, and has anti-inflammatory properties. It is used as a meat tenderizer in the food industry.

Label: Bromelains

NCI Thesaurus Code: C28134 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0006217  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ananase
Bromelain
bromelain
BROMELAINS
Bromelains
Bromelase
EC 3.4.22.33
Extranase
Pineapple Protease

External Source Codes: 
CAS Registry Number 9001-00-7 (see NLM ChemIDplus info)
FDA UNII Code U182GP2CF3
NSC Code 163804 (see NCI DTP info)
PDQ Closed Trial Search ID 459959
PDQ Open Trial Search ID 459959 (check for NCI PDQ open clinical trial info)
UMLS CUI C0006217

Other Properties:
     Name Value (qualifiers indented underneath)
code C28134
Contributing_Source FDA
Legacy_Concept_Name Bromelain
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Enzyme

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28134

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