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Version: 17.12d (Release date: 2017-12-26)
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Verpasep Caltespen (Code C2811)

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Terms & Properties

Preferred Name: Verpasep Caltespen

Definition: A recombinant chimeric protein composed of the heat shock protein 65 (Hsp65) from Mycobacterium bovis, and the human papilloma viral (HPV) protein E7. Hsp65, similar to other members of its family of proteins, elicits a strong immune response and may be used to design vaccines against a number of different cancers. E7 protein is involved in carcinogenesis of anal and cervical tumors, and represents a tumor antigen that may be specifically targeted by lymphocytes. (NCI04)

NCI-GLOSS Definition: A substance that is being studied in the prevention of cancer. It belongs to the family of drugs called fusion proteins.

Display Name: Verpasep Caltespen

Label: Verpasep Caltespen

NCI Thesaurus Code: C2811 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1327844  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Bovine HSP fusion with E7 of HPV16
HPV 16 E7/HSP65 Vaccine
HPV E7 Peptide Epitope Vaccine
HspE7 Therapeutic Vaccine
Verpasep Caltespen

External Source Codes: 
CAS Registry Number 295371-00-5 (see NLM ChemIDplus info)
NSC Code 713219 (see NCI DTP info)
PDQ Closed Trial Search ID 269165
PDQ Open Trial Search ID 269165 (check for NCI PDQ open clinical trial info)
UMLS CUI C1327844

Other Properties:
     Name Value (qualifiers indented underneath)
code C2811
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name HspE7
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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