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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Anti-Thymocyte Globulin (Code C278)

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Terms & Properties

Preferred Name: Anti-Thymocyte Globulin

Definition: A purified gamma immunoglobulin (IgG) with immunosuppressive activity. Obtained from animals that have been immunized with human thymocytes, antithymocyte globulin (ATG) specifically recognizes and destroys T lymphocytes. Although not completely understood, the mechanism of action appears to involve T lymphocyte clearance from the circulation and modulation of T lymphocyte activity. Administering ATG with chemotherapy prior to stem cell transplantation may reduce the risk of graft-versus-host (GVH) disease.

NCI-GLOSS Definition: Serum from blood that contains antibodies that bind to human T cells. Antithymocyte globulin is given to a patient before a stem cell transplant to kill T cells and lower the risk of graft-versus-host disease (GVHD). It is also used to treat GVHD and after a kidney transplant to help keep the body from rejecting the kidney.

Display Name: Anti-Thymocyte Globulin

Label: Anti-Thymocyte Globulin

NCI Thesaurus Code: C278 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0305055  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-Thymocyte Globulin
antithymocyte globulin
Antithymocyte Globulin
Antithymocyte Serum

External Source Codes: 
PDQ Closed Trial Search ID 39337
PDQ Open Trial Search ID 39337 (check for NCI PDQ open clinical trial info)
UMLS CUI C0305055

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Heart and renal transplantation rejection, prophylaxis
code C278
Contributing_Source CTRP
Legacy_Concept_Name Antithymocyte_Globulin
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  


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