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Version: 17.06d (Release date: 2017-06-26)
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Vandetanib (Code C2737)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Vandetanib

Definition: An orally bioavailable 4-anilinoquinazoline. Vandetanib selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGFR2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability. This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell proliferation and migration and angiogenesis.

NCI-GLOSS Definition: A substance being studied in the treatment of lung cancer and other types of cancer. It may block the growth and spread of tumor cells and prevent the growth of new blood vessels that tumors need to grow. Vandetanib is a type of tyrosine kinase inhibitor and a type of antiangiogenesis agent.

Display Name: Vandetanib

Label: Vandetanib

NCI Thesaurus Code: C2737 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1384659  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AZD6474
Caprelsa
Vandetanib
VANDETANIB
vandetanib
Zactima
ZD-6474
ZD6474

External Source Codes: 
CAS Registry Number 443913-73-3 (see NLM ChemIDplus info)
FDA UNII Code YO460OQ37K
ChEBI ID CHEBI:49960 (see ChEBI info)
PDQ Closed Trial Search ID 269177
PDQ Open Trial Search ID 269177 (check for NCI PDQ open clinical trial info)
UMLS CUI C1384659

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Thyroid Cancer
Chemical_Formula C22H24BrFN4O2
code C2737
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name ZD-6474
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2737

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