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Version: 16.11d (Release date: 2016-11-28)
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Vascular Disrupting Agent ZD6126 (Code C2736)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Vascular Disrupting Agent ZD6126

Definition: A water-soluble phosphate prodrug of N-acetylcolchinol with potential antiangiogenesis and antineoplastic activities. ZD-6126 is converted in vivo into N-acetylcolchinol. N-acetylcolchinol binds to and destabilizes the tubulin cytoskeleton of endothelial cells in tumor blood vessels, which may result in tumor endothelial cell apoptosis, the selective occlusion of tumor blood vessels, cessation of tumor blood flow, and tumor necrosis.

NCI-GLOSS Definition: A substance that has been studied in the treatment of several types of cancer. ZD6126 destroys blood vessels in tumors and may prevent the growth of new blood vessels that tumors need to grow. It is a type of vascular targeting agent and a type of antiangiogenesis agent.

Label: Vascular Disrupting Agent ZD6126

NCI Thesaurus Code: C2736 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1122628  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ANG453
N-[(5S)-6,7-Dihydro-9,10,11-trimethoxy-3-(phosphonooxy)-5H-dibenzo[a,c]cyclohepten-5-yl]acetamide
N-acetylcochinol-O-phosphate
Vascular Disrupting Agent ZD6126
ZD-6126
ZD6126
ZM-445526

External Source Codes: 
CAS Registry Number 219923-05-4 (see NLM ChemIDplus info)
FDA UNII Code GBO3S6M9W7
PDQ Closed Trial Search ID 353153
PDQ Open Trial Search ID 353153 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 18219445 (see PubMed Primary Reference info)
UMLS CUI C1122628

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C20H24NO8P
code C2736
Contributing_Source FDA
Legacy_Concept_Name ZD-6126
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2736

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