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Version: 17.06d (Release date: 2017-06-26)
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ISIS 5132 (Code C2721)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: ISIS 5132

Definition: A synthetic, 20-base antisense oligodeoxynucleotide that hybridizes to c-raf kinase messenger RNA. ISIS 5132 has been shown to specifically suppress Raf-1 expression both in vitro and in vivo. Raf-1 serine/threonine kinase functions as a critical effector of Ras-mediated signal transduction; constitutive activation of this pathway directly contributes to malignant transformation. (NCI04)

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer.

Label: ISIS 5132

NCI Thesaurus Code: C2721 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0389883  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
c-RAF Antisense
CGP69846A
CGP 69846A
ISIS-5132
ISIS 5132
ISIS 5132/CGP69846A
RAF-IK Antisense ODN

External Source Codes: 
NSC Code 719336 (see NCI DTP info)
PDQ Closed Trial Search ID 42994
PDQ Open Trial Search ID 42994 (check for NCI PDQ open clinical trial info)
UMLS CUI C0389883

Other Properties:
     Name Value (qualifiers indented underneath)
code C2721
Legacy_Concept_Name ISIS_5132
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2721

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