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Version: 17.06d (Release date: 2017-06-26)
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Pelitinib (Code C2713)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Pelitinib

Definition: A 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. Pelitinib irreversibly binds covalently to epidermal growth factor receptors (EGFR) ErbB-1, -2 and -4, thereby inhibiting receptor phosphorylation and signal transduction and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress these receptors.

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called epidermal growth factor receptor inhibitors.

Display Name: Pelitinib

Label: Pelitinib

NCI Thesaurus Code: C2713 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0961045  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(2E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
EKB-569
EKB 569
Pelitinib
PELITINIB
WAY-EKB 569

External Source Codes: 
CAS Registry Number 257933-82-7 (see NLM ChemIDplus info)
FDA UNII Code X5DWL380Z6
ChEBI ID CHEBI:38927 (see ChEBI info)
NSC Code 729742 (see NCI DTP info)
PDQ Closed Trial Search ID 352165
PDQ Open Trial Search ID 352165 (check for NCI PDQ open clinical trial info)
UMLS CUI C0961045

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C24H23ClFN5O2
code C2713
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name EKB-569
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2713

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