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Version: 17.06d (Release date: 2017-06-26)
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Vincristine Sulfate Liposome (Code C2702)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Vincristine Sulfate Liposome

Definition: A sphingomyelin/cholesterol liposomal formulation of vincristine sulfate with potential antineoplastic activity. Vincristine, a vinca alkaloid isolated from the plant Vinca rosea, irreversibly binds to and stabilizes tubulin, thereby interrupting microtubule assembly/disassembly dynamics, thereby preventing the formation of the mitotic spindle and leading to cell cycle arrest in metaphase. Liposomal encapsulation prolongs bioavailability of vincristine, increases its delivery to tumor tissues and reduces its toxicity profile. Compared to standard liposomal delivery, sphingosomal drug delivery further increases circulation time of serum drug and enhances drug accumulation at tumor sites, thereby leading to a further increase in efficacy.

Display Name: Vincristine Sulfate Liposome

Label: Vincristine Sulfate Liposome

NCI Thesaurus Code: C2702 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0935690  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Marqibo
Vincristine Sulfate Liposome

External Source Codes: 
PDQ Closed Trial Search ID 38100
PDQ Open Trial Search ID 38100 (check for NCI PDQ open clinical trial info)
UMLS CUI C0935690

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For acute lymphoblastic leukemia (ALL)
code C2702
Contributing_Source CTRP
Legacy_Concept_Name Vincristine_Sulfate_Liposomes
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2702

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