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Version: 17.06d (Release date: 2017-06-26)
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Therapeutic Immune Globulin (Code C2701)

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Terms & Properties

Preferred Name: Therapeutic Immune Globulin

Definition: A preparation of plasma proteins derived from the pooled plasma of adult donors. Largely comprised of IgG antibodies, therapeutic immune globulin provides passive immunization by increasing the recipient's serum levels of circulating antibodies. IgG antibodies have multiple functions, including binding to and neutralizing bacterial toxins; opsonization of pathogens; activation of complement; and suppression of pathogenic cytokines and phagocytes through binding to CD5, interleukin-1a (IL-1a), interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and T-cell receptors. Therapeutic immune globulin may diminish pathogenic mechanisms in some autoimmune diseases by binding to and inhibiting the activity of autoantibodies. (NCI04)

NICHD Definition: A blood product derived from pooled IgG antibodies extracted from donor plasma delivered parenterally. It is used to treat multiple disorders, including immunodeficiencies, autoimmune disorders, and active infections.

Display Name: Therapeutic Immune Globulin

Label: Therapeutic Immune Globulin

NCI Thesaurus Code: C2701 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0085297  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Gamimune N
Gammagard S/D
Gamma Globulin
Immune Globulin
Immune Globulin Intravenous
Immune Globulin IV
Iveegam EN
Polygam S/D
Therapeutic Immune Globulin
Therapeutic Immunoglobulin
WinRho SDF

External Source Codes: 
NSC Code 621996 (see NCI DTP info)
PDQ Closed Trial Search ID 40109
PDQ Open Trial Search ID 40109 (check for NCI PDQ open clinical trial info)
UMLS CUI C0085297

Other Properties:
     Name Value (qualifiers indented underneath)
code C2701
Contributing_Source CTRP
Contributing_Source NICHD
Legacy_Concept_Name Therapeutic_Immune_Globulin
NICHD_Hierarchy_Term Immune Globulin
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  


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