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Version: 17.06d (Release date: 2017-06-26)
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Iodine I 131 Monoclonal Antibody CC49-deltaCH2 (Code C2697)

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Terms & Properties

Preferred Name: Iodine I 131 Monoclonal Antibody CC49-deltaCH2

Definition: A radioimmunoconjugate consisting of the humanized CH2 domain-deleted monoclonal antibody CC49 and iodine I 131 with antineoplastic activity. Monoclonal antibody CC49-deltaCH2 targets the tumor-associated glycoprotein 72 (TAG-72) that is expressed by a wide range of human neoplasms including colorectal, gastric, pancreatic, ovarian, endometrial, breast, non-small cell lung, and prostate cancers. Iodine I 131 monoclonal antibody CC49-deltaCH2 binds to tumor cells expressing TAG-72, selectively delivering a cytotoxic dose of beta and gamma radiation.

Display Name: Iodine I 131 Monoclonal Antibody CC49-deltaCH2

Label: Iodine I 131 Monoclonal Antibody CC49-deltaCH2

NCI Thesaurus Code: C2697 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1134477  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
131I-HuCC49-deltaCH2
131I-MOAB CC49-deltaCH2
I131 MOAB CC49-deltaCH2
Iodine I 131 Monoclonal Antibody CC49-deltaCH2

External Source Codes: 
PDQ Closed Trial Search ID 453590
PDQ Open Trial Search ID 453590 (check for NCI PDQ open clinical trial info)
UMLS CUI C1134477

Other Properties:
     Name Value (qualifiers indented underneath)
code C2697
Contributing_Source CTRP
Legacy_Concept_Name Iodine_I_131_Monoclonal_Antibody_CC49-deltaCH2
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2697

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