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Version: 16.10e (Release date: 2016-10-31)
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Erlotinib Hydrochloride (Code C2693)

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Terms & Properties

Preferred Name: Erlotinib Hydrochloride

Definition: The hydrochloride salt of a quinazoline derivative with antineoplastic properties. Competing with adenosine triphosphate, erlotinib reversibly binds to the intracellular catalytic domain of epidermal growth factor receptor (EGFR) tyrosine kinase, thereby reversibly inhibiting EGFR phosphorylation and blocking the signal transduction events and tumorigenic effects associated with EGFR activation.

NCI-GLOSS Definition: A drug used to treat certain types of non-small cell lung cancer. It is also used together with gemcitabine to treat pancreatic cancer and is being studied in the treatment of other types of cancer. Erlotinib hydrochloride is a type of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor.

Display Name: Erlotinib Hydrochloride

Label: Erlotinib Hydrochloride

NCI Thesaurus Code: C2693 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1533491  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CP-358,774
Cp-358,774
Erlotinib Hydrochloride
ERLOTINIB HYDROCHLORIDE
erlotinib hydrochloride
N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride
OSI-774
Tarceva

External Source Codes: 
CAS Registry Number 183319-69-9 (see NLM ChemIDplus info)
FDA UNII Code DA87705X9K
ChEBI ID CHEBI:53509 (see ChEBI info)
NSC Code 718781 (see NCI DTP info)
PDQ Closed Trial Search ID 38428
PDQ Open Trial Search ID 38428 (check for NCI PDQ open clinical trial info)
UMLS CUI C1533491

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Malignant glioma; Locally advanced or metastic non-small cell lung carcinoma; Locally advanced, unresectable or metastatic pancreatic carcinoma
Chemical_Formula C22H23N3O4.HCl
code C2693
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Erlotinib
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2693

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