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Version: 17.12d (Release date: 2017-12-26)
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Nab-paclitaxel (Code C2688)

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Terms & Properties

Preferred Name: Nab-paclitaxel

Definition: A Cremophor EL-free, albumin-stabilized nanoparticle formulation of the natural taxane paclitaxel with antineoplastic activity. Paclitaxel binds to and stabilizes microtubules, preventing their depolymerization and so inhibiting cellular motility, mitosis, and replication. This formulation solubilizes paclitaxel without the use of the solvent Cremophor, thereby permitting the administration of larger doses of paclitaxel while avoiding the toxic effects associated with Cremophor.

NCI-GLOSS Definition: A drug used to treat breast cancer that has spread or that has come back within 6 months after chemotherapy. It is also being studied in the treatment of newly diagnosed breast cancer and other types of cancer. ABI-007 is a type of mitotic inhibitor.

Display Name: Paclitaxel Albumin-Stabilized Nanoparticle Formulation

Label: Nab-paclitaxel

NCI Thesaurus Code: C2688 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1134696  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ABI 007
Albumin-bound Paclitaxel
Albumin-Stabilized Nanoparticle Paclitaxel
Nanoparticle Albumin-bound Paclitaxel
Nanoparticle Paclitaxel
nanoparticle paclitaxel
Paclitaxel Albumin-Stabilized Nanoparticle Formulation
paclitaxel albumin-stabilized nanoparticle formulation
Protein-bound Paclitaxel
protein-bound paclitaxel

External Source Codes: 
NSC Code 736631 (see NCI DTP info)
PDQ Closed Trial Search ID 38690
PDQ Open Trial Search ID 38690 (check for NCI PDQ open clinical trial info)
UMLS CUI C1134696

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Metastatic breast cancer
code C2688
Contributing_Source CTRP
Legacy_Concept_Name ABI-007
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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