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Version: 17.12d (Release date: 2017-12-26)
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Ziv-Aflibercept (Code C2682)

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Terms & Properties

Preferred Name: Ziv-Aflibercept

Definition: A recombinant protein comprised of epitopes of the extracellular domains of human vascular endothelial growth factor receptors (VEGFR) fused to the constant region (Fc) of human IgG1 with potential antiangiogenic activity. Afilbercept, functioning as a soluble decoy receptor, binds to pro-angiogenic vascular endothelial growth factors (VEGFs), thereby preventing VEGFs from binding to their endogenous receptors. Disruption of the binding of VEGFs to their cellular receptors may result in the inhibition of tumor angiogenesis, metastasis, and ultimately tumor regression.

NCI-GLOSS Definition: A substance being studied in the treatment of several types of cancer. Vascular endothelial growth factor trap blocks the action of vascular endothelial growth factor (VEGF) and may prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent.

Display Name: Ziv-Aflibercept

Label: Ziv-Aflibercept

NCI Thesaurus Code: C2682 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1134659  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
vascular endothelial growth factor trap
Vascular Endothelial Growth Factor Trap
VEGF Trap R1R2

External Source Codes: 
CAS Registry Number 862111-32-8 (see NLM ChemIDplus info)
FDA UNII Code 15C2VL427D
NSC Code 724770 (see NCI DTP info)
PDQ Closed Trial Search ID 38652
PDQ Open Trial Search ID 38652 (check for NCI PDQ open clinical trial info)
UMLS CUI C1134659

Other Properties:
     Name Value (qualifiers indented underneath)
code C2682
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name VEGF_Trap
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  


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