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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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ABT-751 (Code C2679)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: ABT-751

Definition: An orally bioavailable antimitotic sulfonamide. ABT- 751 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of microtubules, thereby preventing tumor cell replication. This agent also disrupts tumor neovascularization, reducing tumor blood flow and so inducing a cytotoxic effect. (NCI04)

NCI-GLOSS Definition: A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called sulfonamides.

Display Name: ABT-751

Label: ABT-751

NCI Thesaurus Code: C2679 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1134654  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ABT-751
E7010
N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide

External Source Codes: 
CAS Registry Number 141430-65-1 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 38646
PDQ Open Trial Search ID 38646 (check for NCI PDQ open clinical trial info)
UMLS CUI C1134654

Other Properties:
     Name Value (qualifiers indented underneath)
code C2679
Contributing_Source CTRP
Legacy_Concept_Name ABT-751
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2679

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