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National Cancer Institute
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Version: 16.11d (Release date: 2016-11-28)
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Beta-Glucan (Code C2678)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Beta-Glucan

Definition: A polysaccharide isolated from the cell walls of bacteria, plants, and fungi with immunostimulant and antineoplastic activities. In a solubilized form, beta-glucan binds to a lectin site within complement receptor 3 (CR3) on leukocytes, priming the receptor to trigger cytotoxic degranulation of leukocytes when leukocyte CR3 binds to complement 3 (iC3b)-coated tumors. Thus, the attachment of beta-glucan to CR3 of circulating leukocytes simulates leukocytes to kill iC3b-coated tumor cells in the same way as they kill iC3b-coated yeast. (NCI04)

NCI-GLOSS Definition: A substance found in bacteria, plants, and certain foods, such as baker's yeast, cereal grains, and mushrooms. It is a type of polysaccharide that is made of a string of glucose (sugar) molecules joined together. Beta-glucan may stimulate the immune system and help kill cancer cells. It is being studied in the treatment of cancer. It is a type of biological response modifier.

Display Name: Beta-Glucan

Label: Beta-Glucan

NCI Thesaurus Code: C2678 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1134651  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Beta-Glucan
beta-glucan

External Source Codes: 
ChEBI ID CHEBI:28793 (see ChEBI info)
PDQ Closed Trial Search ID 38642
PDQ Open Trial Search ID 38642 (check for NCI PDQ open clinical trial info)
UMLS CUI C1134651

Other Properties:
Name Value (qualifiers indented underneath)
code C2678
Contributing_Source CTRP
Legacy_Concept_Name Beta-Glucan
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2678

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