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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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G207 (Code C2676)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: G207

Definition: A neuroattenuated, replication-competent, recombinant herpes simplex virus-1 (HSV-1) with potential oncolytic activity. Upon intracerebral administration, oncolytic HSV-1 G207 preferentially replicates within glioma cells, which may elicit tumor-specific systemic immune and cytotoxic T lymphocyte (CTL) responses in addition to direct cytopathic effects. Derived from wild-type HSV-1 strain F, this agent has been neuroattenuated by deletions in both copies of the gamma34.5 gene, the major determinant of HSV neurovirulence. In addition, the HSV-1 gene UL39, encoding the viral ribonucleotide reductase large subunit infected cell protein 6 (ICP6), has been inactivated through the insertion of the Escherichia coli lacZ gene. By inactivating UL39, viral ribonucleotide reductase activity is disrupted, resulting in the inhibition of nucleotide metabolism and viral DNA synthesis in nondividing cells but not in dividing cells.

Label: G207

NCI Thesaurus Code: C2676 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1134718  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
G207

External Source Codes: 
PDQ Closed Trial Search ID 38634
PDQ Open Trial Search ID 38634 (check for NCI PDQ open clinical trial info)
UMLS CUI C1134718

Other Properties:
     Name Value (qualifiers indented underneath)
code C2676
Legacy_Concept_Name G207
Semantic_Type Pharmacologic Substance
Semantic_Type Virus

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2676

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