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Version: 17.06d (Release date: 2017-06-26)
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Epothilone D (Code C2672)

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Terms & Properties

Preferred Name: Epothilone D

Definition: A natural polyketide compound isolated from the myxobacterium Sorangium cellulosum. Also known as desoxyepothilone B, epothilone D binds to tubulin and inhibits the disassembly of microtubules, resulting in the inhibition of mitosis, cellular proliferation, and cell motility. (NCI04)

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It is a type of mitotic inhibitor and epothilone.

Label: Epothilone D

NCI Thesaurus Code: C2672 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0962559  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(4S-(4R*,7S,8R*,9R*,13Z,16R*(E)))-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-(1-methyl-2-(2-methyl-4-thiazolyl)ethenyl)oxacyclohexadec-13-ene-2,6-dione
12,13-Deoxyepothilone B
Desoxyepothilone B
Epothilone D
epothilone D
EPOTHILONE D
KOS-862
KOS 862

External Source Codes: 
CAS Registry Number 189453-10-9 (see NLM ChemIDplus info)
FDA UNII Code T0358E0YUF
NSC Code 703147 (see NCI DTP info)
PDQ Closed Trial Search ID 38604
PDQ Open Trial Search ID 38604 (check for NCI PDQ open clinical trial info)
UMLS CUI C0962559

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C27H41NO5S
code C2672
Contributing_Source FDA
Legacy_Concept_Name Epothilone_D
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2672

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