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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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NY-ESO-B (Code C26680)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: NY-ESO-B

Definition: A tumor-associated antigen belonging to the family of immunogenic testicular proteins that are aberrantly expressed in human cancers in a lineage-nonspecific fashion. Reverse transcription-PCR analysis showed NY-ESO-1 mRNA expression in a variable proportion of a wide array of human cancers, including melanoma, breast cancer, bladder cancer, prostate cancer, and hepatocellular carcinoma; and restricted expression in normal tissues, with high-level mRNA expression found only in testis and ovary tissues. The gene for NY-ESO-1 maps to Xq28 and codes for an 18-kDa protein having no homology with any known protein. NY-ESO-1 elicits a strong, integrated humoral and cellular immune response in a high proportion of patients with NY-ESO-1-expressing tumors and is under investigation as a cancer immunotherapy agent.

Label: NY-ESO-B

NCI Thesaurus Code: C26680 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1327762  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
PDQ Closed Trial Search ID 257347
PDQ Open Trial Search ID 257347 (check for NCI PDQ open clinical trial info)
UMLS CUI C1327762

Other Properties:
     Name Value (qualifiers indented underneath)
code C26680
Legacy_Concept_Name NY-ESO-B
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  


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