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Version: 17.06d (Release date: 2017-06-26)
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Lenalidomide (Code C2668)

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Terms & Properties

Preferred Name: Lenalidomide

Definition: A thalidomide analog with potential antineoplastic activity. Lenalidomide inhibits TNF-alpha production, stimulates T cells, reduces serum levels of the cytokines vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), and inhibits angiogenesis. This agent also promotes G1 cell cycle arrest and apoptosis of malignant cells.

NCI-GLOSS Definition: A drug that is similar to thalidomide, and is used to treat multiple myeloma and certain types of anemia. It is also being studied in the treatment of other types of cancer. Lenalidomide belongs to the family of drugs called angiogenesis inhibitors.

Display Name: Lenalidomide

Label: Lenalidomide

NCI Thesaurus Code: C2668 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1144149  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
CC-5013
CC5013
CDC 501
Lenalidomide
lenalidomide
LENALIDOMIDE
Revlimid

External Source Codes: 
CAS Registry Number 191732-72-6 (see NLM ChemIDplus info)
FDA UNII Code F0P408N6V4
ChEBI ID CHEBI:63791 (see ChEBI info)
NSC Code 703813 (see NCI DTP info)
PDQ Closed Trial Search ID 38564
PDQ Open Trial Search ID 38564 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 16085014 (see PubMed Primary Reference info)
UMLS CUI C1144149

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Transfusion-dependent anemia due to low- or intermediate-1 risk myelodysplastic syndrome; multiple myeloma
Chemical_Formula C13H13N3O3
code C2668
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name CC-5013
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2668

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